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Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date.

TitleMolecular characterizations of glioblastoma, targeted therapy, and clinical results to date.
Publication TypeJournal Article
Year of Publication2015
AuthorsBastien JIL, McNeill KA, Fine HA
JournalCancer
Volume121
Issue4
Pagination502-16
Date Published2015 Feb 15
ISSN1097-0142
KeywordsAntineoplastic Agents, Brain Neoplasms, Clinical Trials as Topic, Epigenomics, Glioblastoma, Humans, Molecular Targeted Therapy, Neoplasm Proteins, Signal Transduction, Transcriptome
Abstract

During the last decade, extensive multiplatform genome-wide analysis has yielded a wealth of knowledge regarding the genetic and molecular makeup of glioblastoma multiforme (GBM). These profiling studies support the emerging view that GBM comprises a group of highly heterogeneous tumor types, each with its own distinct molecular and genetic signatures. This heterogeneity complicates the process of defining reliable intertumor/intratumor biological states, which will ultimately be needed for classifying tumors and for designing effective customized therapies that target resultant disease pathways. The increased understanding of the molecular pathogenesis of GBM has brought the hope and expectation that such knowledge will lead to better and more rational therapies directed toward specific molecular targets. To date, however, these expectations have largely been unrealized. This review discusses some of the principal genetic and epigenetic aberrations found in GBM that appear promising for targeted therapies now and in the near future, and it offers suggestions for future directions concerning the rather disappointing results of clinical trials to date.

DOI10.1002/cncr.28968
Alternate JournalCancer
PubMed ID25250735