Our Philosophy
Glioblastoma (GBM) exists as one of the most therapeutically intractable and lethal human cancers.
While current glioma models excel at elucidating specific reductionist views of cancer biology, they largely fail in therapeutic screening due to their inability to capture the multifaceted and patient-specific nature of human cancers.
Cancer, however, is not a cell-autonomous disease, but rather one involving complex interactions within its microenvironment and the broader organism.
Our laboratory believes that the next generation of preclinical tumor models will need to be highly contextualized based on the specific tumor type and biological and clinical phenotypes unique to host variables.
Our Approach
Our GBM models must capture this complexity by incorporating the genomic, epigenomic, and transcriptomic heterogeneity of tumors, along with the unique characteristics of the human brain microenvironment, while still being suitable for high-throughput assays.
To address limitations with current preclinical glioblastoma (GBM) models, our laboratory utilizes ‘‘GLICO’’ (cerebral organoid glioma) models to retro-engineer patient-specific GBMs using patient-derived glioma stem cells and human cerebral organoids.
Meet Our Lab Team
The Fine laboratory allows outstanding exposure to and potential involvement in all aspects of translational science and precision medicine while exploring basic mechanistic studies of tumorigenesis using a combination of molecular and computational biology approaches.
Our Research
Our lab is a 2017 recipient of the NIH Directors Pioneer Award, and is a rapidly growing program/laboratory benefitting from exceptional resources, scientific freedom and extraordinary local environment of world-renowned cancer biologists. Our largest and most rapidly growing area of interests are focused in the neuroscience of embryonic stem cell-derived cerebral organoids interfaced with tumor stem cell biology.