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Master regulators, regulatory networks, and pathways of glioblastoma subtypes.

TitleMaster regulators, regulatory networks, and pathways of glioblastoma subtypes.
Publication TypeJournal Article
Year of Publication2014
AuthorsBozdag S, Li A, Baysan M, Fine HA
JournalCancer Inform
Volume13
IssueSuppl 3
Pagination33-44
Date Published2014
ISSN1176-9351
Abstract

Glioblastoma multiforme (GBM) is the most common malignant brain tumor. GBM samples are classified into subtypes based on their transcriptomic and epigenetic profiles. Despite numerous studies to better characterize GBM biology, a comprehensive study to identify GBM subtype- specific master regulators, gene regulatory networks, and pathways is missing. Here, we used FastMEDUSA to compute master regulators and gene regulatory networks for each GBM subtype. We also ran Gene Set Enrichment Analysis and Ingenuity Pathway Analysis on GBM expression dataset from The Cancer Genome Atlas Project to compute GBM- and GBM subtype-specific pathways. Our analysis was able to recover some of the known master regulators and pathways in GBM as well as some putative novel regulators and pathways, which will aide in our understanding of the unique biology of GBM subtypes.

DOI10.4137/CIN.S14027
Alternate JournalCancer Inform
PubMed ID25368508
PubMed Central IDPMC4214595